![\"\"](\"https:\/\/legacy.nau.edu\/wp-content\/uploads\/sites\/79\/Big-island-cropped.jpg\")
<\/a>\nIn the US, Early Childhood Caries is the most prevalent chronic disease in children, occurring 5 times as frequently as asthma, and when left untreated costing $1.6 billion in emergency dental care in 2012 alone. Nationwide, caries rates of Hispanic, Native American, and Native Hawaiian and Other Pacific Islander children, are almost double those of white children. Approximately 52% of pre-school aged Hispanic children (in Yuma County, Arizona) and 50% of NH\/OPI children (on Hawai\u2019i Island) have untreated caries.<\/p>\n
Traditional socioeconomic factors (poverty and access to dental care) explain only a portion of the elevated ECC incidence rates in ethnic minorities, with biological components likely having a strong impact. Infection by bacteria from mutans streptococci group (S. mutans and S. sobrinus), have been implicated as the cause of ECC. When established in the oral cavity, these bacteria metabolize carbohydrates and produce highly acidic byproducts that change the pH of the oral cavity, leading to demineralization of tooth enamel. The impact of the genomics, virulence (acid production), and bacterial load of mutans streptococci in the oral cavity on observed ethnic ECC incidence disparities are unknown but are likely significant. Similarly unknown is the role that preschool classrooms perform in selecting for highly acidic strains of mutans streptococci.<\/p>\n
We have proposed to address these knowledge gaps in our existing project titled: \u201cDefining Microbiological Drivers of Early Childhood Caries in Preschoolers in Southern Arizona\u201d. However, while the parent study is well-poised to explore the biological component of ECC in Hispanic and, to a lesser extent, Native American children, Native Hawaiians and Pacific Islanders are insufficiently represented in Arizona (and elsewhere in the continental US) to draw statistically significant conclusions. With this administrative supplement we propose to focus on disambiguating the biological drivers of dental decay in NH\/OPI children. At 33.9%, the proposed catchment area for this supplement (Hawai\u2019i County, HI), has one of the highest concentrations of Native Hawaiians, per capita, in the country, making it an ideal option to disambiguate NH\/OPI from other ethnicities.<\/p>\n
Specific Aims<\/h3>\n\n- Quantify the impact S. mutans and S. sobrinus genomic diversity (phylogenetic clade membership), virulence, and bacterial load on caries progression and outcomes in Native Hawaiian and Other Pacific Islander children.<\/span><\/li>\n
- Quantify the impact of classroom-based oral microbiome and S. mutants \/ S. sobrinus transmission on caries rates in Native Hawaiian and Other Pacific Islander children.<\/span><\/li>\n<\/ol>\n<\/div><\/div>\n
This supplement is the first large-scale effort to explicitly understand the biological factors driving caries formation, both at home and at the school (or daycare), in NH\/OPI children. Existing continental US-based studies typically do not have sufficient populations (and thus statistical power) to disaggregate NH\/OPI children from the Asian population.\u00a0<\/span><\/p>\n\n\n \n \n In the news Accordion Closed<\/span><\/h4>\n <\/span>\n <\/div>\n <\/a>\n \n \n\nNAU researchers launch first large-scale study of tooth decay among preschoolers in southern Arizona, on island of Hawai’i<\/i><\/b><\/a><\/p>\nResearchers at Northern Arizona University have been working on a major study of 350 minority preschoolers in northern Arizona for three years to demonstrate that biological components combine with socioeconomic factors, including poverty and access to dental care, to increase tooth decay.<\/span><\/p>\n<\/body><\/html>\n\n <\/div>\n<\/div>\n\nStudy name:<\/strong> Defining Microbiological Drivers of Early Childhood Caries in Preschoolers of Native Hawaiian and Other Pacific Islander Descent
\nFunding:<\/strong> This study was funded by NIMHD\/NIH 3U54MD012388-03S2
\nIRB project number:<\/strong> 2020-00156 (UH-Hilo)<\/p>\n
\nAbout the investigators<\/h2>\n\n\n \n![\"Julie](\"https:\/\/legacy.nau.edu\/wp-content\/uploads\/sites\/160\/2018\/10\/Julie-Baldwin_300x300-300x300.jpg\")
<\/p>\n\n<\/div>\n\n\n
\n \nJulie Baldwin, PhD<\/h3>\nPrincipal Investigator, SHERC<\/strong><\/div>\nAdministrative Core Lead<\/strong><\/div>\nRecruitment Core Lead<\/strong><\/div>\nPrincipal Investigator, SHERC Administrative Supplements<\/strong><\/div>\nDirector, Center for Community Health and Engaged Research (CHER)<\/div>\nRegents’ Professor, Department of Health Sciences<\/div>\nEmail:<\/strong> Julie.Baldwin@nau.edu<\/a><\/div>\nPhone:<\/strong> 928-523-6566<\/a><\/div>\nResearch interests: <\/strong>Community-based Participatory Research, HIV\/AIDS & Substance Abuse Prevention, Chronic Disease Prevention, Diverse and Rural Populations<\/div>\n\n<\/div>\n<\/div>\n\n\n \n![\"Viacheslav](\"https:\/\/legacy.nau.edu\/wp-content\/uploads\/sites\/79\/2018\/07\/Slava-Fofanov-square-600x600.jpg\")
<\/a><\/p>\n\n<\/div>\n\n\n\n \nViacheslav “Slava” Fofanov, PhD<\/h3>\n\nCo-Investigator<\/strong><\/div>\nAssociate Director for Research and Graduate Programs in the School of Informatics, Computing and Cyber Systems (SICCS)<\/div>\nEmail: <\/strong>Viacheslav.Fofanov@nau.edu<\/a><\/div>\nResearch interests:<\/strong> Statistical methods, database design, data quality, data entry, and coding, honest broker operations<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n ![\"\"](\"https:\/\/legacy.nau.edu\/wp-content\/uploads\/sites\/79\/Misty-Pachecosquare-600x598.jpg\")
<\/a>\n\n<\/div>\n\n\n\n \nMisty Pacheco, PhD<\/h3>\nCo-Investigator<\/strong><\/div>\n<\/div>\nAssociate Professor and Department Chair of Kinesiology and Exercise Sciences<\/div>\nUniversity of Hawaii at Hilo<\/div>\n
This supplement is the first large-scale effort to explicitly understand the biological factors driving caries formation, both at home and at the school (or daycare), in NH\/OPI children. Existing continental US-based studies typically do not have sufficient populations (and thus statistical power) to disaggregate NH\/OPI children from the Asian population.\u00a0<\/span><\/p>\n\n NAU researchers launch first large-scale study of tooth decay among preschoolers in southern Arizona, on island of Hawai’i<\/i><\/b><\/a><\/p>\n Researchers at Northern Arizona University have been working on a major study of 350 minority preschoolers in northern Arizona for three years to demonstrate that biological components combine with socioeconomic factors, including poverty and access to dental care, to increase tooth decay.<\/span><\/p>\n<\/body><\/html>\n\n <\/div>\n<\/div>\n\n Study name:<\/strong> Defining Microbiological Drivers of Early Childhood Caries in Preschoolers of Native Hawaiian and Other Pacific Islander DescentIn the news Accordion Closed<\/span><\/h4>\n <\/span>\n <\/div>\n <\/a>\n
\nFunding:<\/strong> This study was funded by NIMHD\/NIH 3U54MD012388-03S2
\nIRB project number:<\/strong> 2020-00156 (UH-Hilo)<\/p>\n
\nAbout the investigators<\/h2>\n
<\/p>\n\n<\/div>\n\n\nJulie Baldwin, PhD<\/h3>\n
<\/a><\/p>\n\n<\/div>\n\n\nViacheslav “Slava” Fofanov, PhD<\/h3>\n
<\/a>\n\n<\/div>\n\n\nMisty Pacheco, PhD<\/h3>\n