{"id":8835,"date":"2023-05-25T16:16:49","date_gmt":"2023-05-25T16:16:49","guid":{"rendered":"https:\/\/nau.edu\/sherc\/?page_id=8835"},"modified":"2025-08-12T20:44:21","modified_gmt":"2025-08-12T20:44:21","slug":"ppp-year-2-ladner","status":"publish","type":"page","link":"https:\/\/legacy.nau.edu\/sherc\/ppp-year-2-ladner\/","title":{"rendered":"PPP Year 2: High-throughput characterization of health disparities related to viral infections"},"content":{"rendered":"

Pilot Project, Year 2<\/h1>\n

High-throughput characterization of health disparities related to viral infections<\/h2>\n

Viral pathogens are a significant burden to human health, and despite advances in the development of vaccines and therapeutics, viral diseases are expected to continue to plague the human population for the foreseeable future.<\/p>\n

In fact, changes in human behavior related with modernization and the continued increase in global population size\u00a0are likely to increase the number and severity of outbreaks caused by emerging and re-emerging viral pathogens. While these emerging diseases are of universal concern, historical records clearly demonstrate that particular societal groups typically bear unequal burdens of morbidity and mortality associated with outbreaks of infectious disease.<\/p>\n

In order to address these health disparities, it is critical to understand the differential health burdens resulting from infectious diseases, which are pathogen-specific and vary in space and time. Unfortunately, the currently used DNA- and protein-level detection methods lack the sensitivity and throughput necessary for comprehensive and fine-scale characterization of viral exposure to be conducted broadly within the human population.<\/p>\n

This study used PepSeq technology to develop a sensitive, high-throughput and adaptable assay for characterizing an individual\u2019s nearly complete history of viral exposures within a single reaction. Their work demonstrated the utility of this approach for detecting health disparities through a pilot study in Flagstaff, AZ. They discovered that a better understanding of health disparities is integral to targeting intervention strategies to promote health equity.<\/p>\n

Funding:<\/strong> The study is funded by NIMHD\/NIH U54MD012388<\/p>\n

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About the investigator<\/h2>\n
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Jason Ladner, PhD<\/h3>\n<\/div>\n

Principal Investigator<\/strong><\/p>\n

Assistant Professor, Department of Biological Sciences<\/p>\n<\/div>\n

Email:<\/strong> Jason.Ladner@nau.edu<\/a><\/div>\n
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Publications \u00a0 Accordion Closed<\/span><\/h4>\n <\/span>\n <\/div>\n <\/a>\n
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• Sierra N. Henson, Evan A. Elko, Piotr M. Swiderski, Yong Liang, Anna L. Engelbrektson, Alejandra Piña, Annalee S. Boyle, Zane Fink, Salvatore J. Facista, Vidal Martinez, Fatima Rahee, Annabelle Brown, Erin J. Kelley, Georgia A. Nelson, Isaiah Raspet, Heather L. Mead, John A. Altin & Jason T. Ladner<\/strong> (2022). PepSeq: a fully in vitro platform for highly multiplexed serology using customizable DNA-barcoded peptide libraries<\/a>. Nature Protocols. 2023, 18, 396-423.<\/p>\n

• Zane W. Fink, Vidal Martinez, John Altin, and Jason T. Ladner<\/strong> (2020). PepSIRF: a flexible and comprehensive tool for the analysis of data from highly-multiplexed DNA-barcoded peptide assays<\/a>. arXiv.<\/p>\n<\/body><\/html>\n\n <\/div>\n<\/div>\n\n\n

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Pilot Project, Year 2 High-throughput characterization of health disparities related to viral infections Viral pathogens are a significant burden to human health, and despite advances in the development of vaccines and therapeutics, viral diseases are expected to continue to plague the human population for the foreseeable future. In fact, changes in human behavior related with […]<\/p>\n","protected":false},"author":286,"featured_media":8973,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ring_central_script_selection":""},"acf":[],"_links":{"self":[{"href":"https:\/\/legacy.nau.edu\/sherc\/wp-json\/wp\/v2\/pages\/8835"}],"collection":[{"href":"https:\/\/legacy.nau.edu\/sherc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/legacy.nau.edu\/sherc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/legacy.nau.edu\/sherc\/wp-json\/wp\/v2\/users\/286"}],"replies":[{"embeddable":true,"href":"https:\/\/legacy.nau.edu\/sherc\/wp-json\/wp\/v2\/comments?post=8835"}],"version-history":[{"count":5,"href":"https:\/\/legacy.nau.edu\/sherc\/wp-json\/wp\/v2\/pages\/8835\/revisions"}],"predecessor-version":[{"id":9031,"href":"https:\/\/legacy.nau.edu\/sherc\/wp-json\/wp\/v2\/pages\/8835\/revisions\/9031"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/legacy.nau.edu\/sherc\/wp-json\/wp\/v2\/media\/8973"}],"wp:attachment":[{"href":"https:\/\/legacy.nau.edu\/sherc\/wp-json\/wp\/v2\/media?parent=8835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}